They include two rare coins struck by Jewish forces revolting against Roman rule in the first century A.D.
Heritage Auctions said the sale will be March 8 and 9.
Included is one of only two known Year 1 prototype silver shekels from 66 A.D. The other is in the collection of the Israel Museum. They contain the inscription "Jerusalem is holy," an image of a ritual chalice and three pomegranates.
A Year 1 silver quarter shekel, from 70 A.D., also is only one of two known examples.
An anonymous Los Angeles-area private collector assembled the coins, known as the Shoshana Collection, over four decades.